Standard adjuvant treatment for HER2-positive breast cancer patients, following primary surgery for their cancer, is Trastuzumab (Herceptin)–typically used in combination with chemotherapy. However, a new study by researchers at Fox Chase Cancer Center reports that it may be safe to treat these patients with both Trastuzumab and adjuvant radiation therapy.

The study will be presented at the annual meeting of the American Society for Radiation Oncology (ASTRO).

“Our study evaluated the skin toxicity and early cardiac toxicity of concurrent Trastuzumab and radiation therapy treatment in the adjuvant setting,” says Penny Anderson, M.D., radiation oncologist at Fox Chase and lead author on the study. “We found that there was an extremely low rate of acute radiation dermatitis and cardiac toxicity in patients who received this type of treatment.”

The study followed 85 breast cancer patients who received adjuvant Trastuzumab while also receiving a course of adjuvant radiation therapy, as well as 85 breast cancer patients who only received adjuvant radiation therapy. Acute dermatitis was grade 2 in 15% and grade 3 in 2% of the patients receiving concurrent treatment, likewise grade 2 and grade 3 dermatitis was observed in 14% and 2 % of patients only receiving radiation therapy–there was only one patient who developed a grade > 2. There were no differences in cardiac toxicity between the two groups.

“The results of this study show that it is safe to use both Trastuzumab and radiation therapy in an adjuvant setting, when clinically indicated,” adds Anderson. “We would like to see longer follow-up to evaluate the potential differences in late cardiac toxicity.”  Adapted from materials provided by Fox Chase Cancer Center, via EurekAlert!, a service of AAAS.

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  1. ive played both horde and alliance. but since i played alliance for so long when i played horde i didn’t like it. not just because the alliance twons i went to attacked me xD. anyway i think im just iased so i wanted to hear fellow wow playes oppinions on this. Horde vs Alliance.

  2. Regarding World War II, when did the alliance between the USA and the Soviet Union officially begin? Was there some kind of document that was signed? I know the Soviet Union declared war on Germany sometime in the summer of 1942 and the US did the same later that year but… when can we say that the alliance between these two powers officially begin and through what act?

    Thank you!

  3. Thanks, but actually, I did not ask for the reasons of Nazi-Japanese alliance. I asked how the Nazi regime explained to the Germans themselves that they are now partners with an “inferior”, an Asiatic race. The Japanese like the Nazis were anti-Americans but Nazism was about a lot more, with race such a huge part of it.

  4. toysruslover says:

    what is the alliance like with Australia and America, i have always wondered what it is actually like. could someone please answer this for me.

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